Previous research was conducted into phenotypic characterisation of crossbred between indigenous and exotic strains of chickens as part of the evaluation of Nigeria’s animal resources. The population of local chickens in Nigeria is estimated to be 120 million and the contribution being made by chickens to food and income needs of the people, especially rural dwellers, justified this emphasis.

Current research is in animal molecular genetics and biotechnology. Working with Dr Ikhide Imumorin at Cornell University, Ithaca, USA and other researchers at University of Agriculture, Abeokuta, I have diversified my PhD research work into ruminant genetics with specialisation in molecular animal genetics. My doctoral thesis research was titled “Molecular Genetic Variation and Diversity of Toll-like Receptor Genes in Nigerian Goat Breeds”.

Toll-like receptor (TLR) family of proteins are vital to immune function through the sensing of pathogenic agents and initiation of an appropriate immune response. Toll-like receptors are a highly conserved group of proteins that have been identified in organisms as diverse as insects and mammals. TLRs provide the host with a means of discriminating foreign from self and as such, they function at the earliest stages of immune development. Variations in TLR abundance have been associated with altered immune responsiveness. Very little molecular genetic analysis has been carried out in Nigerian livestock to understand genetic diversity, population structure and possible applications to marker-assisted selection. The aim of the project is to screen several TLR genes for single nucleotide polymorphisms (SNPs), ascertain their molecular diversity and association with physiological indices in Nigerian goats. So far, I have successfully cloned and sequenced TLR1, TLR2, TLR3 and TLR5 genes in Nigerian goats by PCR, whereupon some SNPs were identified and analysed in these goat populations. Results of this work are being prepared for submission to scientific journal.

Last Updated on May 13, 2019 by admin

Leave a Reply